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This antibody recognizes actin isotypes alpha of smooth muscle and those cells with myofibroblast differentiation. It labels smooth muscular cells, myofibroblasts, and myoepithelial cells.
Using this antibody with other myogenic markers such as muscle actin, desmin and vimentin will be very helpful for differentiation of tumor from muscle origin. It is a useful marker for the identification for soft tissue tumors with muscle differentiation, i.e. leiomyomas and leiomyosarcomas. It is a useful marker for distinction benign proliferative lesions of the breast from neoplastic proliferations. |
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