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CD20 is expressed on B-cell precursors and mature B cells, but is lost in plasma cells. CD20 is almost always expressed in B cell lymphomas of small cell type, prolymphocytic leukemia, follicular center cell lymphomas, large or small cell types of both diffuse and follicular patterns, monocytoid lymphomas, mantle cell lymphomas, hairy cell leukemias/lymphomas and immunoblastic lymphomas.
Clone L26 is the most commonly used of the CD20 antibodies. This antibody has been one of the most important tools in diagnostic pathology for the diagnosis of B-cell neoplasms. |
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