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D2-40, also known as Podoplanin and Lymphatic Endothelial Cell Marker. It is expressed in lymphatic endothelium, and was found in lymphangiomas, Kaposi sarcomas, a subset of
angiosarcomas with lymphatic differentiation, epithelioid mesotheliomas, hemangioblastomas, seminomas.
D2-40 is a useful marker in identification of lymphatic invasion of primary tumors. D2-40 has also known to be a specific marker for cells of mesothelial origin e.g. mesothelioma. |
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