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This antibody reacts with the lambda light chain of human immunoglobulins (Ig) irrespective of the Ig isotype (Ig G, IgM, and IgA). This antibody also reactes with free lambda light chains. It does not react with the kappa light chain.
In normal lymphoid tissue, lambda-positive plasma cells are strongly labeled, whereas B-lymphocyte staining is weaker. Extracellular Ig within blood vessels and connective tissue tends to yield a diffuse staining pattern. Cells containing absorbed Ig (e.g. Reed-Sternberg cells, dendritic cells, macrophages or monocytes) may also be labeled.
Neoplastic B cell proliferations express either kappa or lambda light chains. Therefore, the antibody may be used for detecting surface Ig on neoplastic plasma cell and B cells. Positive results aid in the classification of B-cell lymphomas by demonstrating their light chain restriction. Differential identification is aided by the results from a panel of antibodies. Human Ig light chain antibodies must always be interpreted as a pair (kappa and lambda), with the absence or paucity of one antibody nearly as important as the excess of the other. |
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