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The antibody labels Ki-67, a proliferation-associated nuclear protein expressed during all active
phases of the cell cycle. Quantitative determination of the fraction of cells which stain positive for
the Ki-67 nuclear antigen has been demonstrated to be a highly accurate way of assessing the
fraction of proliferating cells within a given tissue. Estimation of the cell proliferation index in tumor
cells is valuable as a prognostic indicator. |
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