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C-Kit (CD117) is expressed on hematopoietic stem/progenitor cells, master cells, Cajal cells, mammalian ductal epithelia, melanocytes, and basal cells of skin.
The antibody is a useful tool for the identification of cancers expressing c-Kit, e.g. small cell lung carcinoma (SLCL), mast cell diseases, Ewing sarcoma, and may aid in the differentiation between gastrointestinal stromal tumors (GISTs) and other intra-abdominal mesenchymal tumors along with other markers, e.g. CD34 and S-100. |
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